STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB1DNA damage-binding protein 1; Component of light signal transduction machinery. Involved in fruit pigmentation and fruit nutritional quality. Acts as a negative regulator of fruit pigmentation. Probably acts by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes. Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5 (1095 aa)    
Predicted Functional Partners:
cul4
Uncharacterized protein; Cullin 4 ; Belongs to the cullin family
   
 0.999
Solyc08g008120.2.1
Uncharacterized protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin ligase, Det1/DDB1-complexing (In /.../:IPR018276); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink)
   
 0.999
Det1
Light-mediated development protein DET1; Component of light signal transduction machinery. Involved in fruit pigmentation and fruit nutritional quality. Acts as a negative regulator of fruit pigmentation. Probably acts by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes. Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5; Belongs to the DET1 family
    
 
 0.998
Solyc09g031610.2.1
Protein damaged dna-binding 2; Uncharacterized protein; Damaged DNA binding 2
   
 0.998
Solyc02g086470.2.1
Denticleless protein homolog a; Uncharacterized protein; Transducin/WD40 repeat-like superfamily protein
   
 0.997
Solyc12g088340.1.1
annotation not available
    
 0.997
Solyc08g074370.2.1
DDB1- and CUL4-associated factor homolog 1; Uncharacterized protein; DDB1-CUL4 associated factor 1
   
 
 0.996
Cullin-4
Uncharacterized protein; Belongs to the cullin family
   
 0.995
Solyc04g080160.2.1
COP9 signalosome complex subunit 4; Proteasome component (PCI) domain protein
   
 0.995
Solyc01g021640.2.1
Uncharacterized protein loc101252105 isoform x1; Uncharacterized protein; Transducin/WD40 repeat-like superfamily protein
   
 0.994
Your Current Organism:
Solanum lycopersicum
NCBI taxonomy Id: 4081
Other names: Lycopersicon esculentum, Lycopersicon esculentum Mill., Lycopersicon esculentum var. esculentum, S. lycopersicum, Solanum esculentum, Solanum esculentum Dunal, Solanum lycopersicum L., tomato
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