STRINGSTRING
loxD protein (Solanum lycopersicum) - STRING interaction network
"loxD" - Lipoxygenase in Solanum lycopersicum
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
loxDLipoxygenase ; Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding (908 aa)    
Predicted Functional Partners:
aos
Allene oxide synthase ; Cytochrome P450 of the CYP74A subfamily involved in the biosynthesis of jasmonic acid from lipoxygenase-derived hydroperoxides of free fatty acids. Catalyzes the synthesis of unstable allene oxide, which is further converted spontaneously by hydrolysis or cyclization. Can use 13S-hydroperoxy- 9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) and 13S- hydroperoxy-9(Z),11(E)-octadecadienoic acid (13-HPOD) as substrates (534 aa)
     
 
  0.958
AOS2
Allene oxide synthase ; Cytochrome P450 of the CYP74A subfamily involved in the biosynthesis of jasmonic acid from lipoxygenase-derived hydroperoxides of free fatty acids. Catalyzes the synthesis of unstable allene oxide, which is further converted spontaneously by hydrolysis or cyclization. Metabolizes 13- but not 9- hydroperoxides of linoleic and linolenic acids. Can use 15S- hydroperoxy-11(Z),13(E),17(Z)-eicosatrienoic acid (15-HPET) and 13S-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) as substrates, but only 50% activity with 13S-hydroperoxy- 9(Z),11(E)-octadecadien [...] (510 aa)
     
 
  0.950
HPL
Fatty acid hydroperoxide lyase ; Cytochrome P450 of the CYP74B subfamily involved in the biosynthesis of traumatin and C6 aldehydes (PubMed-10923789, PubMed-10859201). Metabolizes 13- but not 9-hydroperoxides of linoleic and linolenic acids (PubMed-10923789, PubMed-10859201). Can use 15S-hydroperoxy-11(Z),13(E),17(Z)-eicosatrienoic acid (15- HPET) and 13S-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) as substrates, but only 5% activity with 13S- hydroperoxy-9(Z),11(E)-octadecadienoic acid (13-HPOD) (PubMed-10859201). Produces n-hexanal and 12-oxo-9(Z)-dodecanoic acid fro [...] (476 aa)
         
  0.918
LOC543818
Lipoxygenase ; Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding (862 aa)
         
0.915
LOX1.1
Linoleate 9S-lipoxygenase A ; Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (860 aa)
         
0.915
Solyc08g029000.2.1
Lipoxygenase ; Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding (861 aa)
         
0.915
AOS3
Cytochrome P450 CYP74C3 ; Cytochrome P450 metabolizing both 13- and 9- hydroperoxides of linoleic and linolenic acids, but with a marked preference for 9-hydroperoxy fatty acids (PubMed-12351632, PubMed-18780387). Has no activity toward 13S-hydroperoxy- 9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) (PubMed-18780387). Catalyzes not only the synthesis of allene oxide, but also its hydrolysis and cyclization (PubMed-18780387). The first step is the synthesis of (12Z)-9,10-epoxyoctadeca-10,12- dienoic acid (9,10-EOD) and the final products are (9R)-alpha- ketol and the racemic cis-10-ox [...] (491 aa)
         
  0.907
Solyc02g087110.2.1
Uncharacterized protein (632 aa)
         
  0.900
LOC543896
Alpha-DOX2 (642 aa)
         
  0.900
LOC543895
Alpha-DOX1 (639 aa)
         
  0.900
Your Current Organism:
Solanum lycopersicum
NCBI taxonomy Id: 4081
Other names: Lycopersicon, Lycopersicon (Mill.) Seithe, Lycopersicon esculentum, Lycopersicon esculentum Mill., Lycopersicon esculentum var. esculentum, Lycopersicon lycopersicum, S. lycopersicum, Solanum esculentum, Solanum esculentum Dunal, Solanum lycopersicum, Solanum lycopersicum L., tomato
Server load: low (12%) [HD]