STRINGSTRING
LOC544263 protein (Solanum lycopersicum) - STRING interaction network
"LOC544263" - Dihydroneopterin aldolase in Solanum lycopersicum
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC544263Dihydroneopterin aldolase; Hop-interacting protein THI048 ; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin (130 aa)    
Predicted Functional Partners:
Solyc05g012090.2.1
Dihydropterin pyrophosphokinase-dihydropteroate synthase (512 aa)
 
 
  0.992
LOC543831
GTP cyclohydrolase I ; GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid (456 aa)
 
 
  0.811
LOC543912
Aminodeoxychorismate synthase/glutamine amidotransferase ; Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity (902 aa)
         
  0.741
LOC778238
4-amino-4-deoxychorismate lyase (395 aa)
       
  0.643
Solyc01g109830.2.1
Bifunctional dihydrofolate reductase-thymidylate synthase ; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (527 aa)
       
  0.642
Solyc06g051900.2.1
Uncharacterized protein (554 aa)
       
  0.640
Solyc05g052920.2.1
Tetrahydrofolylpolyglutamate synthase ; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis (543 aa)
       
  0.574
Solyc04g016550.2.1
Uncharacterized protein (401 aa)
       
  0.574
Solyc12g088220.1.1
Branched-chain-amino-acid aminotransferase (380 aa)
       
  0.499
Solyc07g062810.2.1
Uncharacterized protein (349 aa)
       
  0.499
Your Current Organism:
Solanum lycopersicum
NCBI taxonomy Id: 4081
Other names: Lycopersicon, Lycopersicon (Mill.) Seithe, Lycopersicon esculentum, Lycopersicon esculentum Mill., Lycopersicon esculentum var. esculentum, Lycopersicon lycopersicum, S. lycopersicum, Solanum esculentum, Solanum esculentum Dunal, Solanum lycopersicum, Solanum lycopersicum L., tomato
Server load: low (8%) [HD]