Groups of genes that are frequently observed in each other's genomic neighborhood.
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Steroid 5 alpha reductase DET2 ; Involved in a reduction step in the biosynthesis of the plant steroid, brassinolide. Can use progesterone, testosterone, androstenedione and campestenone as substrate (257 aa)
Predicted Functional Partners:
CYP90A1-like protein (487 aa)
Cytochrome P450 (491 aa)
Uncharacterized protein (494 aa)
Uncharacterized protein (465 aa)
Cytochrome P450 (480 aa)
Uncharacterized protein (477 aa)
Uncharacterized protein (131 aa)
COP1 homolog (677 aa)
Single-stranded DNA-binding protein WHY1, chloroplastic (268 aa)