node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0363 | Mlab_0980 | Mlab_0363 | Mlab_0980 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | PFAM: transferase hexapeptide repeat containing protein. | 0.572 |
Mlab_0363 | Mlab_1616 | Mlab_0363 | Mlab_1616 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | 6-pyruvoyl-tetrahydropterin synthase-like protein. | 0.418 |
Mlab_0363 | mptA | Mlab_0363 | Mlab_0018 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.527 |
Mlab_0980 | Mlab_0363 | Mlab_0980 | Mlab_0363 | PFAM: transferase hexapeptide repeat containing protein. | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | 0.572 |
Mlab_0980 | mptA | Mlab_0980 | Mlab_0018 | PFAM: transferase hexapeptide repeat containing protein. | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.581 |
Mlab_1147 | moaA | Mlab_1147 | Mlab_1255 | TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase. | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.818 |
Mlab_1147 | mptA | Mlab_1147 | Mlab_0018 | TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase. | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.804 |
Mlab_1147 | ndk | Mlab_1147 | Mlab_1500 | TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.902 |
Mlab_1147 | ribB | Mlab_1147 | Mlab_0396 | TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.803 |
Mlab_1616 | Mlab_0363 | Mlab_1616 | Mlab_0363 | 6-pyruvoyl-tetrahydropterin synthase-like protein. | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | 0.418 |
Mlab_1616 | mptA | Mlab_1616 | Mlab_0018 | 6-pyruvoyl-tetrahydropterin synthase-like protein. | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.594 |
ilvC | mptA | Mlab_0019 | Mlab_0018 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.568 |
moaA | Mlab_1147 | Mlab_1255 | Mlab_1147 | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase. | 0.818 |
moaA | mptA | Mlab_1255 | Mlab_0018 | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.901 |
moaA | ndk | Mlab_1255 | Mlab_1500 | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.804 |
moaA | ribB | Mlab_1255 | Mlab_0396 | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.906 |
mptA | Mlab_0363 | Mlab_0018 | Mlab_0363 | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | 0.527 |
mptA | Mlab_0980 | Mlab_0018 | Mlab_0980 | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | PFAM: transferase hexapeptide repeat containing protein. | 0.581 |
mptA | Mlab_1147 | Mlab_0018 | Mlab_1147 | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase. | 0.804 |
mptA | Mlab_1616 | Mlab_0018 | Mlab_1616 | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 6-pyruvoyl-tetrahydropterin synthase-like protein. | 0.594 |