node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0218 | Mlab_0933 | Mlab_0218 | Mlab_0933 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region. | 0.480 |
Mlab_0218 | Mlab_1304 | Mlab_0218 | Mlab_1304 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: GCN5-related N-acetyltransferase; Radical SAM domain protein. | 0.549 |
Mlab_0218 | Mlab_1400 | Mlab_0218 | Mlab_1400 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS domain protein. | 0.445 |
Mlab_0218 | dphB | Mlab_0218 | Mlab_0386 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.880 |
Mlab_0218 | eif2b | Mlab_0218 | Mlab_1249 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor 2 subunit beta (aeIF-2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.527 |
Mlab_0218 | fusA | Mlab_0218 | Mlab_1613 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] | 0.976 |
Mlab_0384 | Mlab_0387 | Mlab_0384 | Mlab_0387 | PFAM: iron dependent repressor; FeoA family protein. | PFAM: Protein of unknown function DUF357. | 0.597 |
Mlab_0384 | dphB | Mlab_0384 | Mlab_0386 | PFAM: iron dependent repressor; FeoA family protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.628 |
Mlab_0387 | Mlab_0384 | Mlab_0387 | Mlab_0384 | PFAM: Protein of unknown function DUF357. | PFAM: iron dependent repressor; FeoA family protein. | 0.597 |
Mlab_0387 | dphB | Mlab_0387 | Mlab_0386 | PFAM: Protein of unknown function DUF357. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.818 |
Mlab_0434 | Mlab_1304 | Mlab_0434 | Mlab_1304 | PFAM: protein of unknown function RIO1. | SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: GCN5-related N-acetyltransferase; Radical SAM domain protein. | 0.424 |
Mlab_0434 | Mlab_1400 | Mlab_0434 | Mlab_1400 | PFAM: protein of unknown function RIO1. | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS domain protein. | 0.460 |
Mlab_0434 | dphB | Mlab_0434 | Mlab_0386 | PFAM: protein of unknown function RIO1. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.646 |
Mlab_0434 | eif2b | Mlab_0434 | Mlab_1249 | PFAM: protein of unknown function RIO1. | Translation initiation factor 2 subunit beta (aeIF-2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.556 |
Mlab_0933 | Mlab_0218 | Mlab_0933 | Mlab_0218 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.480 |
Mlab_0933 | dphB | Mlab_0933 | Mlab_0386 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.807 |
Mlab_0933 | fusA | Mlab_0933 | Mlab_1613 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region. | Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] | 0.744 |
Mlab_1100 | dphB | Mlab_1100 | Mlab_0386 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.686 |
Mlab_1100 | fusA | Mlab_1100 | Mlab_1613 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region. | Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] | 0.720 |
Mlab_1304 | Mlab_0218 | Mlab_1304 | Mlab_0218 | SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: GCN5-related N-acetyltransferase; Radical SAM domain protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.549 |