node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0427 | Mlab_0429 | Mlab_0427 | Mlab_0429 | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | PFAM: protein of unknown function DUF169. | 0.664 |
Mlab_0427 | Mlab_0431 | Mlab_0427 | Mlab_0431 | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | 0.478 |
Mlab_0427 | Mlab_0795 | Mlab_0427 | Mlab_0795 | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.537 |
Mlab_0427 | eif5a | Mlab_0427 | Mlab_0426 | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | Translation initiation factor 5A (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.732 |
Mlab_0427 | nadK | Mlab_0427 | Mlab_0428 | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.985 |
Mlab_0429 | Mlab_0427 | Mlab_0429 | Mlab_0427 | PFAM: protein of unknown function DUF169. | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | 0.664 |
Mlab_0429 | Mlab_0430 | Mlab_0429 | Mlab_0430 | PFAM: protein of unknown function DUF169. | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | 0.443 |
Mlab_0429 | Mlab_0431 | Mlab_0429 | Mlab_0431 | PFAM: protein of unknown function DUF169. | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | 0.554 |
Mlab_0429 | eif5a | Mlab_0429 | Mlab_0426 | PFAM: protein of unknown function DUF169. | Translation initiation factor 5A (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.498 |
Mlab_0429 | nadK | Mlab_0429 | Mlab_0428 | PFAM: protein of unknown function DUF169. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.664 |
Mlab_0430 | Mlab_0429 | Mlab_0430 | Mlab_0429 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | PFAM: protein of unknown function DUF169. | 0.443 |
Mlab_0430 | Mlab_0431 | Mlab_0430 | Mlab_0431 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | 0.913 |
Mlab_0431 | Mlab_0427 | Mlab_0431 | Mlab_0427 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | D-fructose 1,6-bisphosphatase; PFAM: inositol monophosphatase. | 0.478 |
Mlab_0431 | Mlab_0429 | Mlab_0431 | Mlab_0429 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | PFAM: protein of unknown function DUF169. | 0.554 |
Mlab_0431 | Mlab_0430 | Mlab_0431 | Mlab_0430 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | 0.913 |
Mlab_0431 | Mlab_0685 | Mlab_0431 | Mlab_0685 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. | 0.437 |
Mlab_0431 | Mlab_0795 | Mlab_0431 | Mlab_0795 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.977 |
Mlab_0431 | carS | Mlab_0431 | Mlab_0318 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.910 |
Mlab_0431 | eif5a | Mlab_0431 | Mlab_0426 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | Translation initiation factor 5A (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.456 |
Mlab_0431 | lig | Mlab_0431 | Mlab_0620 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.423 |