node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pcal_0222 | Pcal_0224 | Pcal_0222 | Pcal_0224 | PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain; KEGG: pai:PAE0318 hypothetical protein. | Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). | 0.757 |
Pcal_0222 | queF-L | Pcal_0222 | Pcal_0221 | PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain; KEGG: pai:PAE0318 hypothetical protein. | GTP cyclohydrolase I; Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group. Can use neither glutamine nor asparagine as amino donor in vitro, is only able to utilize free ammonium. However, the enzyme might function in vivo with a partner that serves to generate ammonium; Belongs to the archaeosine synthase type 2 family. | 0.557 |
Pcal_0224 | Pcal_0222 | Pcal_0224 | Pcal_0222 | Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). | PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain; KEGG: pai:PAE0318 hypothetical protein. | 0.757 |
Pcal_0224 | Pcal_1063 | Pcal_0224 | Pcal_1063 | Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). | KEGG: pai:PAE2137 hypothetical protein. | 0.414 |
Pcal_0224 | guaA | Pcal_0224 | Pcal_1723 | Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.738 |
Pcal_0224 | queF-L | Pcal_0224 | Pcal_0221 | Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). | GTP cyclohydrolase I; Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group. Can use neither glutamine nor asparagine as amino donor in vitro, is only able to utilize free ammonium. However, the enzyme might function in vivo with a partner that serves to generate ammonium; Belongs to the archaeosine synthase type 2 family. | 0.531 |
Pcal_0512 | Pcal_1063 | Pcal_0512 | Pcal_1063 | PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I. | KEGG: pai:PAE2137 hypothetical protein. | 0.866 |
Pcal_0512 | guaA | Pcal_0512 | Pcal_1723 | PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.433 |
Pcal_0512 | queC | Pcal_0512 | Pcal_0202 | PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I. | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.553 |
Pcal_0512 | queE | Pcal_0512 | Pcal_0642 | PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.734 |
Pcal_0512 | queF-L | Pcal_0512 | Pcal_0221 | PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I. | GTP cyclohydrolase I; Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group. Can use neither glutamine nor asparagine as amino donor in vitro, is only able to utilize free ammonium. However, the enzyme might function in vivo with a partner that serves to generate ammonium; Belongs to the archaeosine synthase type 2 family. | 0.553 |
Pcal_1063 | Pcal_0224 | Pcal_1063 | Pcal_0224 | KEGG: pai:PAE2137 hypothetical protein. | Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). | 0.414 |
Pcal_1063 | Pcal_0512 | Pcal_1063 | Pcal_0512 | KEGG: pai:PAE2137 hypothetical protein. | PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I. | 0.866 |
Pcal_1063 | Pcal_1212 | Pcal_1063 | Pcal_1212 | KEGG: pai:PAE2137 hypothetical protein. | TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165; KEGG: pai:PAE0573 hypothetical protein. | 0.420 |
Pcal_1063 | guaA | Pcal_1063 | Pcal_1723 | KEGG: pai:PAE2137 hypothetical protein. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.735 |
Pcal_1063 | queC | Pcal_1063 | Pcal_0202 | KEGG: pai:PAE2137 hypothetical protein. | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.984 |
Pcal_1063 | queE | Pcal_1063 | Pcal_0642 | KEGG: pai:PAE2137 hypothetical protein. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.977 |
Pcal_1063 | queF-L | Pcal_1063 | Pcal_0221 | KEGG: pai:PAE2137 hypothetical protein. | GTP cyclohydrolase I; Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group. Can use neither glutamine nor asparagine as amino donor in vitro, is only able to utilize free ammonium. However, the enzyme might function in vivo with a partner that serves to generate ammonium; Belongs to the archaeosine synthase type 2 family. | 0.925 |
Pcal_1063 | tgtA | Pcal_1063 | Pcal_2149 | KEGG: pai:PAE2137 hypothetical protein. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.513 |
Pcal_1212 | Pcal_1063 | Pcal_1212 | Pcal_1063 | TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165; KEGG: pai:PAE0573 hypothetical protein. | KEGG: pai:PAE2137 hypothetical protein. | 0.420 |