node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pcal_0129 | Pcal_0450 | Pcal_0129 | Pcal_0450 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | 0.430 |
Pcal_0129 | Pcal_1894 | Pcal_0129 | Pcal_1894 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | Phosphoribosylamine--glycine ligase; KEGG: pai:PAE0216 phosphoribosylglycinamide synthetase (GARS) (purD); TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | 0.988 |
Pcal_0129 | Pcal_2033 | Pcal_0129 | Pcal_2033 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | PFAM: Protein of unknown function DUF1297; Protein of unknown function DUF1246; KEGG: pai:PAE0604 hypothetical protein. | 0.951 |
Pcal_0129 | hisF | Pcal_0129 | Pcal_0137 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.828 |
Pcal_0129 | hisH | Pcal_0129 | Pcal_0130 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.916 |
Pcal_0129 | purA | Pcal_0129 | Pcal_0128 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.999 |
Pcal_0129 | purP | Pcal_0129 | Pcal_0449 | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | Protein of unknown function DUF1297; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.951 |
Pcal_0448 | Pcal_0450 | Pcal_0448 | Pcal_0450 | PFAM: aldo/keto reductase; KEGG: pai:PAE0606 oxidoreductase, conjectural. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | 0.597 |
Pcal_0448 | Pcal_0451 | Pcal_0448 | Pcal_0451 | PFAM: aldo/keto reductase; KEGG: pai:PAE0606 oxidoreductase, conjectural. | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF1780 acetolactate synthase large subunit. | 0.589 |
Pcal_0448 | purP | Pcal_0448 | Pcal_0449 | PFAM: aldo/keto reductase; KEGG: pai:PAE0606 oxidoreductase, conjectural. | Protein of unknown function DUF1297; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.768 |
Pcal_0450 | Pcal_0129 | Pcal_0450 | Pcal_0129 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | PFAM: fumarate lyase; KEGG: pai:PAE0972 adenylosuccinate lyase. | 0.430 |
Pcal_0450 | Pcal_0448 | Pcal_0450 | Pcal_0448 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | PFAM: aldo/keto reductase; KEGG: pai:PAE0606 oxidoreductase, conjectural. | 0.597 |
Pcal_0450 | Pcal_0451 | Pcal_0450 | Pcal_0451 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF1780 acetolactate synthase large subunit. | 0.868 |
Pcal_0450 | purA | Pcal_0450 | Pcal_0128 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.411 |
Pcal_0450 | purP | Pcal_0450 | Pcal_0449 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | Protein of unknown function DUF1297; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.517 |
Pcal_0451 | Pcal_0448 | Pcal_0451 | Pcal_0448 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF1780 acetolactate synthase large subunit. | PFAM: aldo/keto reductase; KEGG: pai:PAE0606 oxidoreductase, conjectural. | 0.589 |
Pcal_0451 | Pcal_0450 | Pcal_0451 | Pcal_0450 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF1780 acetolactate synthase large subunit. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: formate dehydrogenase. | 0.868 |
Pcal_0451 | purP | Pcal_0451 | Pcal_0449 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF1780 acetolactate synthase large subunit. | Protein of unknown function DUF1297; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.506 |
Pcal_0593 | Pcal_2033 | Pcal_0593 | Pcal_2033 | PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 conserved hypothetical protein; Belongs to the UPF0201 family. | PFAM: Protein of unknown function DUF1297; Protein of unknown function DUF1246; KEGG: pai:PAE0604 hypothetical protein. | 0.630 |
Pcal_0593 | purP | Pcal_0593 | Pcal_0449 | PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 conserved hypothetical protein; Belongs to the UPF0201 family. | Protein of unknown function DUF1297; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.621 |