STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (368 aa)    
Predicted Functional Partners:
Pcal_0896
PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); KEGG: pai:PAE1924 3-phosphoshikimate 1-carboxyvinyltransferase.
 
 0.999
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.996
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.990
Pcal_0912
PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: pai:PAE2460 anthranilate synthase component I.
 
 
 0.953
Pcal_1209
PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: pai:PAE2460 anthranilate synthase component I.
 
 
 0.952
Pcal_1210
Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pai:PAE2459 anthranilate synthase component II.
  
 
 0.952
Pcal_1211
KEGG: pai:PAE2458 tryptophan synthase alpha subunit; TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase, alpha chain.
  
  
 0.879
aroD
Chorismate mutase / 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
 
 
 0.872
Pcal_0133
PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase.
 
  
 0.816
Pcal_0089
PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase.
  
  
 0.785
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
Server load: low (28%) [HD]