STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXHeat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; KEGG: pai:PAE3461 heat shock protein, htpX homolog, conjectural; Belongs to the peptidase M48B family. (344 aa)    
Predicted Functional Partners:
Pcal_0382
PFAM: GHMP kinase; KEGG: pai:PAE3407 hypothetical protein.
  
    0.868
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.821
Pcal_1661
Ala-tRNA(Pro) hydrolase; PFAM: Threonyl/alanyl tRNA synthetase, SAD; KEGG: pai:PAE2317 alanyl-tRNA synthetase related protein.
  
    0.723
Pcal_0360
PFAM: ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE2901 hypothetical protein.
  
    0.676
Pcal_0415
PFAM: ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE2039 moxR related protein.
  
    0.676
Pcal_1686
ABC transporter related protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; ABC transporter related; Possible metal-binding region in RNase L inhibitor, RLI; SMART: AAA ATPase; KEGG: pai:PAE2352 RNase L inhibitor homolog.
  
    0.623
Pcal_1190
Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: pai:PAE3465 molybdenum cofactor biosynthesis protein.
   
   0.599
Pcal_1976
PFAM: peptidase M48, Ste24p; KEGG: pai:PAE3547 heat shock protein, HtpX homolog, conjectural.
 
 
   0.572
Pcal_1458
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE2594 uroporphyrinogen-III synthase (HemD), conjectural.
 
    0.558
Pcal_1402
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; tryptophan halogenase; KEGG: pai:PAE2649 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase).
  
  
 0.542
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.