node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GFO_0212 | GFO_0216 | GFO_0212 | GFO_0216 | Surface antigen D15 family outer membrane protein. | Protein containing CBS domains. | 0.605 |
GFO_0212 | GFO_0218 | GFO_0212 | GFO_0218 | Surface antigen D15 family outer membrane protein. | Alpha/beta fold hydrolase. | 0.456 |
GFO_0212 | pdxA | GFO_0212 | GFO_3339 | Surface antigen D15 family outer membrane protein. | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. | 0.465 |
GFO_0212 | pdxJ | GFO_0212 | GFO_0217 | Surface antigen D15 family outer membrane protein. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.644 |
GFO_0212 | ppnK | GFO_0212 | GFO_0215 | Surface antigen D15 family outer membrane protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.597 |
GFO_0216 | GFO_0212 | GFO_0216 | GFO_0212 | Protein containing CBS domains. | Surface antigen D15 family outer membrane protein. | 0.605 |
GFO_0216 | GFO_0218 | GFO_0216 | GFO_0218 | Protein containing CBS domains. | Alpha/beta fold hydrolase. | 0.612 |
GFO_0216 | pdxJ | GFO_0216 | GFO_0217 | Protein containing CBS domains. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.564 |
GFO_0216 | ppnK | GFO_0216 | GFO_0215 | Protein containing CBS domains. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.795 |
GFO_0218 | GFO_0212 | GFO_0218 | GFO_0212 | Alpha/beta fold hydrolase. | Surface antigen D15 family outer membrane protein. | 0.456 |
GFO_0218 | GFO_0216 | GFO_0218 | GFO_0216 | Alpha/beta fold hydrolase. | Protein containing CBS domains. | 0.612 |
GFO_0218 | GFO_0219 | GFO_0218 | GFO_0219 | Alpha/beta fold hydrolase. | OMPP1/FadL/TodX family outer membrane protein transport protein. | 0.519 |
GFO_0218 | pdxJ | GFO_0218 | GFO_0217 | Alpha/beta fold hydrolase. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.797 |
GFO_0218 | ppnK | GFO_0218 | GFO_0215 | Alpha/beta fold hydrolase. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.571 |
GFO_0219 | GFO_0218 | GFO_0219 | GFO_0218 | OMPP1/FadL/TodX family outer membrane protein transport protein. | Alpha/beta fold hydrolase. | 0.519 |
GFO_0219 | pdxJ | GFO_0219 | GFO_0217 | OMPP1/FadL/TodX family outer membrane protein transport protein. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.526 |
dxs | pdxJ | GFO_3470 | GFO_0217 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.594 |
dxs | ppnK | GFO_3470 | GFO_0215 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.654 |
era | pdxJ | GFO_2991 | GFO_0217 | GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.660 |
ilvC | pdxJ | GFO_2110 | GFO_0217 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.752 |