STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (254 aa)    
Predicted Functional Partners:
pyrF
KEGG: blo:BL0791 4.1e-64 pyrF; orotidine 5'-phosphate decarboxylase K01591; COG: COG0284 Orotidine-5-phosphate decarboxylase; Psort location: Cytoplasmic, score: 8.87; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
 
 0.999
pyrK
Oxidoreductase NAD-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
 
 0.997
pyrD
Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.996
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
 
 0.956
carB
KEGG: cpe:CPE2572 0. carB; carbamoyl-phosphate synthetase catalytic subunit K01955; COG: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Psort location: Cytoplasmic, score: 8.87.
  
 
 0.955
pyrB
KEGG: cac:CAC2654 8.0e-107 aspartate carbamoyltransferase catalytic subunit K00609; COG: COG0540 Aspartate carbamoyltransferase, catalytic chain; Psort location: Cytoplasmic, score: 9.98; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
  
  
 0.953
carA
KEGG: ldb:Ldb1070 1.2e-110 carA2a; carbamoyl-phosphate synthase small chain K01954; COG: COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family.
  
  
 0.938
EDR47902.1
Putative permease; KEGG: bcz:BCZK0244 4.4e-05 guanine-hypoxanthine permease; xanthine/uracil permease family protein K06901; COG: COG2233 Xanthine/uracil permeases; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.927
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.888
prs
Ribose-phosphate diphosphokinase; KEGG: cac:CAC0819 9.8e-102 phosphoribosylpyrophosphate synthetase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase; Psort location: CytoplasmicMembrane, score: 7.80; Belongs to the ribose-phosphate pyrophosphokinase family.
  
 
 0.797
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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