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dnaN protein (Pseudoflavonifractor capillosus) - STRING interaction network
"dnaN" - Beta sliding clamp in Pseudoflavonifractor capillosus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
dnaNBeta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...] (370 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (889 aa)
 
  0.992
holA
KEGG- gme-Gmet_2298 1.0e-28 DNA polymerase III, delta subunit K02340; COG- COG1466 DNA polymerase III, delta subunit; Psort location- Cytoplasmic, score-8.96 (347 aa)
 
  0.980
EDN01033.1
Uncharacterized protein; Psort location- Cytoplasmic, score-8.96 (274 aa)
   
  0.977
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (367 aa)
 
   
  0.976
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity (596 aa)
 
  0.970
EDM99386.1
Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (784 aa)
     
 
  0.966
EDM98720.1
KEGG- tte-TTE1818 0. dnaE; DNA polymerase III alpha subunit K02337; COG- COG0587 DNA polymerase III, alpha subunit; Psort location- Cytoplasmic, score-9.97 (1161 aa)
   
  0.966
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box)- 5’-TTATC[CA]A[CA]A-3’. DnaA binds to ATP and to acidic phospholipids (426 aa)
 
 
  0.953
EDN00937.1
KEGG- cpe-CPE1401 2.5e-32 probable DNA polymerase III epsilon chain K02342; COG- COG0847 DNA polymerase III, epsilon subunit and related 3-5 exonucleases; Psort location- Cytoplasmic, score-8.96 (191 aa)
     
  0.945
EDM99274.1
5’-3’ exonuclease, N-terminal resolvase-like domain protein; KEGG- msm-MSMEG_3839 1.6e-11 DNA polymerase I K00961; COG- COG0749 DNA polymerase I - 3-5 exonuclease and polymerase domains (302 aa)
     
  0.940
Your Current Organism:
Pseudoflavonifractor capillosus
NCBI taxonomy Id: 411467
Other names: Bacteroides capillosus ATCC 29799, P. capillosus ATCC 29799, Pseudoflavonifractor capillosus, Pseudoflavonifractor capillosus ATCC 29799, Pseudoflavonifractor capillosus ATCC29799, Pseudoflavonifractor capillosus str. ATCC 29799, Pseudoflavonifractor capillosus strain ATCC 29799
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