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lepA protein (Pseudoflavonifractor capillosus) - STRING interaction network
"lepA" - Ribosomal back-translocase LepA in Pseudoflavonifractor capillosus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lepARibosomal back-translocase LepA ; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (602 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1 ; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (355 aa)
 
   
  0.881
rplM
50S ribosomal protein L13 ; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (148 aa)
 
 
  0.829
pheS
Phenylalanyl-tRNA synthetase alpha subunit (341 aa)
   
   
  0.829
gidA
Glucose-inhibited division protein A ; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (621 aa)
 
   
  0.816
obg
GTP-binding protein Obg ; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (425 aa)
 
   
  0.769
BACCAP_02380
Translation elongation factor G (690 aa)
 
   
  0.762
alaS
Alanyl-tRNA synthetase ; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (890 aa)
 
   
  0.725
BACCAP_00392
Aspartate--tRNA ligase (582 aa)
 
   
  0.707
BACCAP_00900
Glutamate synthase [NADPH], large subunit (1551 aa)
   
   
  0.706
prmC
Protein-glutamine N-methyltransferase PrmC ; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif (287 aa)
 
 
  0.691
Your Current Organism:
Pseudoflavonifractor capillosus
NCBI taxonomy Id: 411467
Other names: Bacillus capillosus, Bacteroides capillosus, Bacteroides capillosus ATCC 29799, P. capillosus, P. capillosus ATCC 29799, Pseudobacterium capillosum, Pseudoflavonifractor, Pseudoflavonifractor Carlier et al. 2010, Pseudoflavonifractor capillosus, Pseudoflavonifractor capillosus ATCC 29799, Pseudoflavonifractor capillosus str. ATCC 29799, Pseudoflavonifractor capillosus strain ATCC 29799, Ristella capillosa
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