STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (466 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.983
sat
Similar to ATP-sulfurylase Tbd_0874 (402 aa). sulfate adenylyltransferase in Thiobacillus denitrificans ATCC 25259.
  
  
 0.979
hemD
uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.967
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.955
COSY_0630
Similar to naphthalene 1,2-dioxygenase ferredoxin component NirD.
  
  
 0.885
narJ
Respiratory nitrate reductase delta subunit.
  
    0.789
hemB
Porphobilinogen synthase; Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.787
cobO
cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
    
 0.717
pitA
Na(+):phosphate symporter.
  
  
 0.712
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.705
Your Current Organism:
Vesicomyosocius okutanii
NCBI taxonomy Id: 412965
Other names: C. Vesicomyosocius okutanii HA, Calyptogena okutanii thioautotrophic gill symbiont HA, Candidatus Vesicomyosocius okutanii HA, Candidatus Vesicomyosocius okutanii str. HA, Candidatus Vesicomyosocius okutanii strain HA
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