node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COSY_0073 | folE2 | COSY_0073 | COSY_0286 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.807 |
COSY_0073 | gltB | COSY_0073 | COSY_0919 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Glutamate synthase (NADPH) large chain. | 0.634 |
COSY_0073 | moaA | COSY_0073 | COSY_0643 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.800 |
COSY_0073 | ndk | COSY_0073 | COSY_0355 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.903 |
COSY_0073 | ribAB | COSY_0073 | COSY_0463 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Bifunctional riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.800 |
COSY_0073 | spoT | COSY_0073 | COSY_0471 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.914 |
aroG | folE2 | COSY_0287 | COSY_0286 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.773 |
aroG | gyrA | COSY_0287 | COSY_0288 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | DNA gyrase subunit A GyrA; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.515 |
aroG | parC | COSY_0287 | COSY_0284 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.526 |
aroG | ptpS | COSY_0287 | COSY_0285 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 6-pyruvoyltetrahydropterin synthase. | 0.773 |
folE2 | COSY_0073 | COSY_0286 | COSY_0073 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.807 |
folE2 | aroG | COSY_0286 | COSY_0287 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.773 |
folE2 | gltB | COSY_0286 | COSY_0919 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Glutamate synthase (NADPH) large chain. | 0.461 |
folE2 | gyrA | COSY_0286 | COSY_0288 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | DNA gyrase subunit A GyrA; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.511 |
folE2 | moaA | COSY_0286 | COSY_0643 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.900 |
folE2 | ndk | COSY_0286 | COSY_0355 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.800 |
folE2 | parC | COSY_0286 | COSY_0284 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.523 |
folE2 | ptpS | COSY_0286 | COSY_0285 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 6-pyruvoyltetrahydropterin synthase. | 0.979 |
folE2 | ribAB | COSY_0286 | COSY_0463 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Bifunctional riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.902 |
folE2 | spoT | COSY_0286 | COSY_0471 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.800 |