node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | COSY_0877 | COSY_0849 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | 0.971 |
hisA | hisC | COSY_0877 | COSY_0853 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.962 |
hisA | hisD | COSY_0877 | COSY_0556 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.982 |
hisA | hisE | COSY_0877 | COSY_0274 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-ATP pyrophosphohydrolase; Similar to the C-terminal region of bifunctional protein HisI (203 aa) in Escherichia coli, phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (EC:3.5.4.19 EC:3.6.1.31). | 0.966 |
hisA | hisF | COSY_0877 | COSY_0028 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | COSY_0877 | COSY_0555 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.970 |
hisA | hisH | COSY_0877 | COSY_0848 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisI | COSY_0877 | COSY_0275 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | COSY_0877 | COSY_0488 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.859 |
hisB | hisA | COSY_0849 | COSY_0877 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.971 |
hisB | hisC | COSY_0849 | COSY_0853 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | COSY_0849 | COSY_0556 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisB | hisE | COSY_0849 | COSY_0274 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | phosphoribosyl-ATP pyrophosphohydrolase; Similar to the C-terminal region of bifunctional protein HisI (203 aa) in Escherichia coli, phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (EC:3.5.4.19 EC:3.6.1.31). | 0.963 |
hisB | hisF | COSY_0849 | COSY_0028 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisB | hisG | COSY_0849 | COSY_0555 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.974 |
hisB | hisH | COSY_0849 | COSY_0848 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | COSY_0849 | COSY_0275 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.984 |
hisB | hisZ | COSY_0849 | COSY_0488 | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.937 |
hisC | hisA | COSY_0853 | COSY_0877 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.962 |
hisC | hisB | COSY_0853 | COSY_0849 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of bifunctional histidine biosynthesis protein HisB (356 aa) in Escherichia coli, histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase (EC:3.1.3.15 EC:4.2.1.19). | 0.999 |