node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COSY_0577 | aroA | COSY_0577 | COSY_0576 | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.994 |
COSY_0577 | pheA | COSY_0577 | COSY_0579 | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | 0.989 |
COSY_0577 | serA | COSY_0577 | COSY_0580 | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | D-isomer specific 2-hydroxyacid dehydrogenase. | 0.559 |
COSY_0577 | serC | COSY_0577 | COSY_0581 | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.729 |
aroA | COSY_0577 | COSY_0576 | COSY_0577 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | 0.994 |
aroA | pheA | COSY_0576 | COSY_0579 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | 0.951 |
aroA | serA | COSY_0576 | COSY_0580 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | D-isomer specific 2-hydroxyacid dehydrogenase. | 0.576 |
aroA | serC | COSY_0576 | COSY_0581 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.802 |
dapD | serC | COSY_0080 | COSY_0581 | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.560 |
pdxA | serC | COSY_0501 | COSY_0581 | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.909 |
pdxA | thrC | COSY_0501 | COSY_0707 | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.900 |
pdxB | serC | COSY_0635 | COSY_0581 | Erythronate-4-phosphate dehyrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.976 |
pheA | COSY_0577 | COSY_0579 | COSY_0577 | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | 0.989 |
pheA | aroA | COSY_0579 | COSY_0576 | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.951 |
pheA | serA | COSY_0579 | COSY_0580 | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | D-isomer specific 2-hydroxyacid dehydrogenase. | 0.820 |
pheA | serB | COSY_0579 | COSY_0257 | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | Phosphoserine phosphatase. | 0.543 |
pheA | serC | COSY_0579 | COSY_0581 | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.976 |
pheA | thrC | COSY_0579 | COSY_0707 | Bifunctional protein PheA; Bifunctional chorismate mutase / prephenate dehydratase in phenylalanine, tyrosine and tryptophan biosynthesis pathway. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.569 |
serA | COSY_0577 | COSY_0580 | COSY_0577 | D-isomer specific 2-hydroxyacid dehydrogenase. | Prephenate dehydrogenase; Similar to the N-terminal region of bifunctional protein TyrA PFL_4310 (741 aa) in Pseudomonas fluorescens Pf-5, prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase (EC:1.2.1.3 EC:5.4.99.5). | 0.559 |
serA | aroA | COSY_0580 | COSY_0576 | D-isomer specific 2-hydroxyacid dehydrogenase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.576 |