STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folEGTP cyclohydrolase I. (193 aa)    
Predicted Functional Partners:
Hbut_0804
Conserved archaeal protein.
  
  
 0.997
Hbut_0178
6-pyruvoyl-tetrahydropterin synthase.
  
 
 0.986
Hbut_1201
Molybdenum cofactor biosynthesis enzyme.
    
 0.911
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
   
 0.869
Hbut_0985
Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.812
Hbut_0138
Ribonucleotide reductase, oxygen sensitive (RNR, class III).
    
  0.803
Hbut_0262
Adenylate cyclase, class 2.
     
  0.800
Hbut_0432
Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.757
queE
Organic radical activating enzyme, NrdG; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
  
 0.743
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
     
 0.661
Your Current Organism:
Hyperthermus butylicus
NCBI taxonomy Id: 415426
Other names: H. butylicus DSM 5456, Hyperthermus butylicus DSM 5456, Hyperthermus butylicus str. DSM 5456, Hyperthermus butylicus strain DSM 5456
Server load: medium (68%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.