node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hbut_0064 | Hbut_1281 | Hbut_0064 | Hbut_1281 | XPD/Rad3 related DNA helicase. | DNA or RNA helicases of superfamily II. | 0.999 |
Hbut_0064 | fen | Hbut_0064 | Hbut_1366 | XPD/Rad3 related DNA helicase. | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | 0.895 |
Hbut_0064 | lig | Hbut_0064 | Hbut_0421 | XPD/Rad3 related DNA helicase. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can use ATP, ADP and GTP, but not CTP, TTP or NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.767 |
Hbut_0064 | mre11 | Hbut_0064 | Hbut_1192 | XPD/Rad3 related DNA helicase. | Predicted DNA repair exonuclease; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.846 |
Hbut_0064 | pcn | Hbut_0064 | Hbut_0018 | XPD/Rad3 related DNA helicase. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.623 |
Hbut_0064 | pcn-2 | Hbut_0064 | Hbut_1286 | XPD/Rad3 related DNA helicase. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.623 |
Hbut_0064 | pcn-3 | Hbut_0064 | Hbut_1645 | XPD/Rad3 related DNA helicase. | DNA polymerase sliding clamp B2; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.623 |
Hbut_0064 | rad50 | Hbut_0064 | Hbut_1193 | XPD/Rad3 related DNA helicase. | Predicted Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.658 |
Hbut_0064 | rfcL | Hbut_0064 | Hbut_0906 | XPD/Rad3 related DNA helicase. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.808 |
Hbut_1281 | Hbut_0064 | Hbut_1281 | Hbut_0064 | DNA or RNA helicases of superfamily II. | XPD/Rad3 related DNA helicase. | 0.999 |
Hbut_1281 | fen | Hbut_1281 | Hbut_1366 | DNA or RNA helicases of superfamily II. | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | 0.918 |
Hbut_1281 | lig | Hbut_1281 | Hbut_0421 | DNA or RNA helicases of superfamily II. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can use ATP, ADP and GTP, but not CTP, TTP or NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.698 |
Hbut_1281 | pcn | Hbut_1281 | Hbut_0018 | DNA or RNA helicases of superfamily II. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.461 |
Hbut_1281 | pcn-2 | Hbut_1281 | Hbut_1286 | DNA or RNA helicases of superfamily II. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.542 |
Hbut_1281 | pcn-3 | Hbut_1281 | Hbut_1645 | DNA or RNA helicases of superfamily II. | DNA polymerase sliding clamp B2; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.461 |
Hbut_1281 | rad50 | Hbut_1281 | Hbut_1193 | DNA or RNA helicases of superfamily II. | Predicted Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.504 |
Hbut_1281 | rfcL | Hbut_1281 | Hbut_0906 | DNA or RNA helicases of superfamily II. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.538 |
fen | Hbut_0064 | Hbut_1366 | Hbut_0064 | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | XPD/Rad3 related DNA helicase. | 0.895 |
fen | Hbut_1281 | Hbut_1366 | Hbut_1281 | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | DNA or RNA helicases of superfamily II. | 0.918 |
fen | lig | Hbut_1366 | Hbut_0421 | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can use ATP, ADP and GTP, but not CTP, TTP or NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.964 |