node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APL_0701 | APL_0853 | APL_0701 | APL_0853 | O-acetylhomoserine (thiol)-lyase. | Methionine synthase II (cobalamin-independent). | 0.910 |
APL_0701 | cysK | APL_0701 | APL_0248 | O-acetylhomoserine (thiol)-lyase. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.941 |
APL_0701 | ilvA | APL_0701 | APL_1455 | O-acetylhomoserine (thiol)-lyase. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.806 |
APL_0701 | luxS | APL_0701 | APL_1216 | O-acetylhomoserine (thiol)-lyase. | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.903 |
APL_0701 | metB | APL_0701 | APL_0683 | O-acetylhomoserine (thiol)-lyase. | Cystathionine gamma-synthase. | 0.928 |
APL_0701 | metC | APL_0701 | APL_0320 | O-acetylhomoserine (thiol)-lyase. | Cystathionine beta-lyase. | 0.935 |
APL_0701 | metE | APL_0701 | APL_1155 | O-acetylhomoserine (thiol)-lyase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.910 |
APL_0701 | thrA | APL_0701 | APL_0250 | O-acetylhomoserine (thiol)-lyase. | Bifunctional aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.889 |
APL_0701 | thrB | APL_0701 | APL_0249 | O-acetylhomoserine (thiol)-lyase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.811 |
APL_0853 | APL_0701 | APL_0853 | APL_0701 | Methionine synthase II (cobalamin-independent). | O-acetylhomoserine (thiol)-lyase. | 0.910 |
APL_0853 | cysK | APL_0853 | APL_0248 | Methionine synthase II (cobalamin-independent). | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.812 |
APL_0853 | ilvA | APL_0853 | APL_1455 | Methionine synthase II (cobalamin-independent). | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.810 |
APL_0853 | luxS | APL_0853 | APL_1216 | Methionine synthase II (cobalamin-independent). | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.908 |
APL_0853 | metB | APL_0853 | APL_0683 | Methionine synthase II (cobalamin-independent). | Cystathionine gamma-synthase. | 0.927 |
APL_0853 | metC | APL_0853 | APL_0320 | Methionine synthase II (cobalamin-independent). | Cystathionine beta-lyase. | 0.927 |
APL_0853 | metE | APL_0853 | APL_1155 | Methionine synthase II (cobalamin-independent). | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |
APL_0853 | thrA | APL_0853 | APL_0250 | Methionine synthase II (cobalamin-independent). | Bifunctional aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.903 |
APL_0853 | thrB | APL_0853 | APL_0249 | Methionine synthase II (cobalamin-independent). | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.811 |
cysK | APL_0701 | APL_0248 | APL_0701 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | O-acetylhomoserine (thiol)-lyase. | 0.941 |
cysK | APL_0853 | APL_0248 | APL_0853 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase II (cobalamin-independent). | 0.812 |