node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APL_0052 | mtn | APL_0052 | APL_1637 | Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.636 |
APL_1202 | metK | APL_1202 | APL_1080 | Modification methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.912 |
APL_1202 | mtn | APL_1202 | APL_1637 | Modification methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.900 |
APL_1635 | dsbA_2 | APL_1635 | APL_1638 | Putative adhesin processing HmwC-like protein; Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose. Likely acts as a key component of a general protein glycosylation system (Probable). | Thiol disulfide oxidoreductase. | 0.444 |
APL_1635 | mtn | APL_1635 | APL_1637 | Putative adhesin processing HmwC-like protein; Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose. Likely acts as a key component of a general protein glycosylation system (Probable). | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.444 |
APL_1635 | rimO | APL_1635 | APL_1636 | Putative adhesin processing HmwC-like protein; Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose. Likely acts as a key component of a general protein glycosylation system (Probable). | Hypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. | 0.906 |
dsbA_2 | APL_1635 | APL_1638 | APL_1635 | Thiol disulfide oxidoreductase. | Putative adhesin processing HmwC-like protein; Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose. Likely acts as a key component of a general protein glycosylation system (Probable). | 0.444 |
dsbA_2 | fkpA | APL_1638 | APL_1640 | Thiol disulfide oxidoreductase. | Putative FKBP-type peptidyl-prolyl cis-trans isomerase. | 0.446 |
dsbA_2 | mtn | APL_1638 | APL_1637 | Thiol disulfide oxidoreductase. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.792 |
dsbA_2 | rimO | APL_1638 | APL_1636 | Thiol disulfide oxidoreductase. | Hypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. | 0.460 |
dsbA_2 | slyX | APL_1638 | APL_1639 | Thiol disulfide oxidoreductase. | SlyX-like protein; Belongs to the SlyX family. | 0.581 |
fkpA | dsbA_2 | APL_1640 | APL_1638 | Putative FKBP-type peptidyl-prolyl cis-trans isomerase. | Thiol disulfide oxidoreductase. | 0.446 |
fkpA | mtn | APL_1640 | APL_1637 | Putative FKBP-type peptidyl-prolyl cis-trans isomerase. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.424 |
fkpA | slyX | APL_1640 | APL_1639 | Putative FKBP-type peptidyl-prolyl cis-trans isomerase. | SlyX-like protein; Belongs to the SlyX family. | 0.571 |
guaA | metK | APL_0592 | APL_1080 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.695 |
guaA | mtn | APL_0592 | APL_1637 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.408 |
luxS | mtn | APL_1216 | APL_1637 | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.984 |
metK | APL_1202 | APL_1080 | APL_1202 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Modification methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.912 |
metK | guaA | APL_1080 | APL_0592 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.695 |
metK | mtn | APL_1080 | APL_1637 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.425 |