node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tlet_0445 | Tlet_0653 | Tlet_0445 | Tlet_0653 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.906 |
Tlet_0445 | fhs | Tlet_0445 | Tlet_1513 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.933 |
Tlet_0445 | fmt | Tlet_0445 | Tlet_0693 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.918 |
Tlet_0445 | folD | Tlet_0445 | Tlet_1514 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
Tlet_0445 | gcvT | Tlet_0445 | Tlet_1959 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.932 |
Tlet_0445 | purH | Tlet_0445 | Tlet_1909 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bca:BCE_0327 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.906 |
Tlet_0445 | purN | Tlet_0445 | Tlet_1910 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.912 |
Tlet_0653 | Tlet_0445 | Tlet_0653 | Tlet_0445 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | 0.906 |
Tlet_0653 | fhs | Tlet_0653 | Tlet_1513 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.976 |
Tlet_0653 | folD | Tlet_0653 | Tlet_1514 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
Tlet_0653 | gcvT | Tlet_0653 | Tlet_1959 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
Tlet_0653 | glyA | Tlet_0653 | Tlet_0763 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
Tlet_0653 | purH | Tlet_0653 | Tlet_1909 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bca:BCE_0327 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.909 |
Tlet_0653 | purN | Tlet_0653 | Tlet_1910 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.997 |
Tlet_0653 | thyX | Tlet_0653 | Tlet_1637 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.909 |
Tlet_1361 | folD | Tlet_1361 | Tlet_1514 | PFAM: methylenetetrahydrofolate reductase; KEGG: gfo:orf331 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.933 |
Tlet_1361 | gcvT | Tlet_1361 | Tlet_1959 | PFAM: methylenetetrahydrofolate reductase; KEGG: gfo:orf331 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.936 |
Tlet_1361 | glyA | Tlet_1361 | Tlet_0763 | PFAM: methylenetetrahydrofolate reductase; KEGG: gfo:orf331 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
Tlet_1361 | thyX | Tlet_1361 | Tlet_1637 | PFAM: methylenetetrahydrofolate reductase; KEGG: gfo:orf331 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.912 |
fhs | Tlet_0445 | Tlet_1513 | Tlet_0445 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tma:TM1560 serine cycle enzyme, putative. | 0.933 |