node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | folD | llmg_1595 | llmg_1693 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.999 |
fhs | glyA | llmg_1595 | llmg_0563 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | GlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
fhs | purB | llmg_1595 | llmg_0783 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | PurB protein; High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.746 |
fhs | purC | llmg_1595 | llmg_0973 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; High confidence in function and specificity; Belongs to the SAICAR synthetase family. | 0.781 |
fhs | purD | llmg_1595 | llmg_0997 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; High confidence in function and specificity; Belongs to the GARS family. | 0.701 |
fhs | purF | llmg_1595 | llmg_0977 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.736 |
fhs | purH | llmg_1595 | llmg_0994 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; High confidence in function and specificity. | 0.981 |
fhs | purM | llmg_1595 | llmg_0987 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamide cyclo-ligase; High confidence in function and specificity. | 0.704 |
fhs | purN | llmg_1595 | llmg_0988 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.968 |
folD | fhs | llmg_1693 | llmg_1595 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 0.999 |
folD | glyA | llmg_1693 | llmg_0563 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | GlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
folD | purA | llmg_1693 | llmg_2201 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.654 |
folD | purB | llmg_1693 | llmg_0783 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PurB protein; High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.779 |
folD | purC | llmg_1693 | llmg_0973 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; High confidence in function and specificity; Belongs to the SAICAR synthetase family. | 0.480 |
folD | purD | llmg_1693 | llmg_0997 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylamine--glycine ligase; High confidence in function and specificity; Belongs to the GARS family. | 0.947 |
folD | purF | llmg_1693 | llmg_0977 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.537 |
folD | purH | llmg_1693 | llmg_0994 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; High confidence in function and specificity. | 0.970 |
folD | purM | llmg_1693 | llmg_0987 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamide cyclo-ligase; High confidence in function and specificity. | 0.593 |
folD | purN | llmg_1693 | llmg_0988 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.971 |
glyA | fhs | llmg_0563 | llmg_1595 | GlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 0.980 |