STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folQHypothetical protein; Probably mediates the removal of pyrophosphate from dihydroneopterin triphosphate (DHNTP), a possible step in the pterin branch of the folate synthesis pathway; Belongs to the Nudix hydrolase family. (166 aa)    
Predicted Functional Partners:
folE
Bifunctional protein folE [Includes: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (7,8 dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6- hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK); GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I)]; High confidence in function and specificity; In the C-terminal section; belongs to the GTP cyclohydrolase I family.
 
 
 0.999
folP
Dihydropteroate synthase; High confidence in function and specificity.
 
   
 0.993
folB
FolB protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
   
 0.988
folC
FolC bifunctional protein [Includes: Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS); Dihydrofolate synthase (EC 6.3.2.12)]; High confidence in function and specificity.
  
  
 0.976
apl
Alkaline phosphatase; PF00597.8: DedA family protein; High confidence in function and specificity.
     
  0.900
ribA
Riboflavin biosynthesis protein ribA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
      
 0.751
dukB
Deoxynucleoside kinase; High confidence in function and specificity.
       0.478
metF
MetF protein; PF02219: Methylenetetrahydrofolate reductase, TIGR00676: 5,10-methylenetetrahydrofolate reductase; High confidence in function and specificity; Belongs to the methylenetetrahydrofolate reductase family.
     
 0.473
pabB
PF00425: chorismate binding enzyme, TIGR00553: para-aminobenzoate synthase, component I; High confidence in function and specificity.
  
  
 0.472
ribH
Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
      
 0.461
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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