STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (325 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.994
Maeo_0184
PFAM: ExsB family protein; KEGG: mmp:MMP1239 hypothetical protein.
  
    0.982
Maeo_0762
PFAM: aminotransferase class-III; KEGG: mja:MJ1300 adenosylmethionine-8-amino-7-oxononanoate aminotransferase (BioA); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.948
Maeo_1029
TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: mja:MJ1619 biotin operon repressor/biotin--[acetyl-CoA-carboxylase] ligase (BirA).
  
 
 0.941
Maeo_1026
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0785 biotin synthetase.
  
  
 
0.924
Maeo_0147
PFAM: protein of unknown function DUF752; KEGG: mja:MJ0670 hypothetical protein.
   
    0.887
Maeo_0106
PFAM: nucleoside recognition domain protein; KEGG: mja:MJ0871 hypothetical protein.
   
    0.848
Maeo_1106
KEGG: mmp:MMP0662 hypothetical protein.
   
    0.848
bioF
8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
 
  
 0.797
bioW
6-carboxyhexanoate--CoA ligase; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
 
  
 0.794
Your Current Organism:
Methanococcus aeolicus
NCBI taxonomy Id: 419665
Other names: M. aeolicus Nankai-3, Methanococcus aeolicus Nankai-3, Methanococcus aeolicus str. Nankai-3, Methanococcus aeolicus strain Nankai-3
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