node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Maeo_0027 | Maeo_0926 | Maeo_0027 | Maeo_0926 | Putative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Purine phosphorylase family 2; Purine nucleoside phosphorylase involved in purine salvage. | 0.989 |
Maeo_0027 | fucA | Maeo_0027 | Maeo_0198 | Putative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.806 |
Maeo_0351 | Maeo_1030 | Maeo_0351 | Maeo_1030 | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; KEGG: mmp:MMP1642 ATP/GTP-binding site motif A (P-loop):small GTP-binding protein domain. | Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. | 0.632 |
Maeo_0351 | fucA | Maeo_0351 | Maeo_0198 | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; KEGG: mmp:MMP1642 ATP/GTP-binding site motif A (P-loop):small GTP-binding protein domain. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.715 |
Maeo_0690 | aroA-2 | Maeo_0690 | Maeo_0316 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mmp:MMP0293 hypothetical protein. | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 0.921 |
Maeo_0690 | fbp | Maeo_0690 | Maeo_0171 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mmp:MMP0293 hypothetical protein. | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). | 0.923 |
Maeo_0690 | fucA | Maeo_0690 | Maeo_0198 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mmp:MMP0293 hypothetical protein. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.920 |
Maeo_0690 | tpiA | Maeo_0690 | Maeo_0315 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mmp:MMP0293 hypothetical protein. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.943 |
Maeo_0926 | Maeo_0027 | Maeo_0926 | Maeo_0027 | Purine phosphorylase family 2; Purine nucleoside phosphorylase involved in purine salvage. | Putative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.989 |
Maeo_0926 | dadD | Maeo_0926 | Maeo_0556 | Purine phosphorylase family 2; Purine nucleoside phosphorylase involved in purine salvage. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.990 |
Maeo_0926 | fucA | Maeo_0926 | Maeo_0198 | Purine phosphorylase family 2; Purine nucleoside phosphorylase involved in purine salvage. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.742 |
Maeo_1030 | Maeo_0351 | Maeo_1030 | Maeo_0351 | Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; KEGG: mmp:MMP1642 ATP/GTP-binding site motif A (P-loop):small GTP-binding protein domain. | 0.632 |
Maeo_1030 | egsA | Maeo_1030 | Maeo_0518 | Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. | Glutamate-1-semialdehyde 2,1-aminomutase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. | 0.682 |
Maeo_1030 | fucA | Maeo_1030 | Maeo_0198 | Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.855 |
Maeo_1030 | tpiA | Maeo_1030 | Maeo_0315 | Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.683 |
aroA-2 | Maeo_0690 | Maeo_0316 | Maeo_0690 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mmp:MMP0293 hypothetical protein. | 0.921 |
aroA-2 | fbp | Maeo_0316 | Maeo_0171 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). | 0.924 |
aroA-2 | fucA | Maeo_0316 | Maeo_0198 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.920 |
aroA-2 | tpiA | Maeo_0316 | Maeo_0315 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.980 |
dadD | Maeo_0926 | Maeo_0556 | Maeo_0926 | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | Purine phosphorylase family 2; Purine nucleoside phosphorylase involved in purine salvage. | 0.990 |