node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Maeo_0230 | Maeo_0345 | Maeo_0230 | Maeo_0345 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | 0.835 |
Maeo_0230 | Maeo_0653 | Maeo_0230 | Maeo_0653 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. | 0.518 |
Maeo_0230 | fen | Maeo_0230 | Maeo_1492 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | XPG I; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genom [...] | 0.922 |
Maeo_0230 | mre11 | Maeo_0230 | Maeo_0712 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.861 |
Maeo_0230 | pcn | Maeo_0230 | Maeo_0699 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.958 |
Maeo_0230 | rad50 | Maeo_0230 | Maeo_0711 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.831 |
Maeo_0230 | radA | Maeo_0230 | Maeo_0982 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.931 |
Maeo_0230 | topA | Maeo_0230 | Maeo_0026 | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.941 |
Maeo_0345 | Maeo_0230 | Maeo_0345 | Maeo_0230 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | 0.835 |
Maeo_0345 | Maeo_0653 | Maeo_0345 | Maeo_0653 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. | 0.927 |
Maeo_0345 | fen | Maeo_0345 | Maeo_1492 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | XPG I; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genom [...] | 0.797 |
Maeo_0345 | mre11 | Maeo_0345 | Maeo_0712 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.970 |
Maeo_0345 | pcn | Maeo_0345 | Maeo_0699 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.985 |
Maeo_0345 | rad50 | Maeo_0345 | Maeo_0711 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.897 |
Maeo_0345 | radA | Maeo_0345 | Maeo_0982 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.961 |
Maeo_0345 | topA | Maeo_0345 | Maeo_0026 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.973 |
Maeo_0653 | Maeo_0230 | Maeo_0653 | Maeo_0230 | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. | PFAM: UvrD/REP helicase; KEGG: fnu:FN0524 DNA helicase II. | 0.518 |
Maeo_0653 | Maeo_0345 | Maeo_0653 | Maeo_0345 | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | 0.927 |
Maeo_0653 | fen | Maeo_0653 | Maeo_1492 | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. | XPG I; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genom [...] | 0.991 |
Maeo_0653 | hjc | Maeo_0653 | Maeo_0617 | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. | Resolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. | 0.469 |