STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tfbTranscription factor TFIIB cyclin-related; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (334 aa)    
Predicted Functional Partners:
tbp
TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
 
 0.999
tfe
Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...]
  
 
 0.999
Maeo_0213
TIGRFAM: transcription factor S; PFAM: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; KEGG: mmp:MMP1429 transcription factor TFIIS:DNA-directed RNA polymerase, M/15 kDa subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
  
 0.995
rpoH
RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
    
 0.992
Maeo_0178
SMART: RNA polymerase Rbp10; KEGG: mmp:MMP0248 DNA-directed RNA polymerase related protein.
   
 0.989
Maeo_1093
PFAM: RNA polymerase Rpb6; KEGG: mmp:MMP1327 DNA-directed RNA polymerase, subunit K.
  
 
 0.987
Maeo_1098
PFAM: RNA polymerase dimerisation; RNA polymerase insert; SMART: RNA polymerase RpoA/D/Rpb3-type; KEGG: mmp:MMP1322 DNA-directed RNA polymerase, subunit D.
   
 0.986
rpoN
RNA polymerase, N/8 Kd subunits; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
   
 0.982
Maeo_0979
PFAM: helicase domain protein; SMART: DEXDc2; helicase c2; DEAD-like helicases; KEGG: mmp:MMP1219 putative DinG ATP-dependent helicase.
    
 0.979
Maeo_0791
PFAM: RNA polymerase Rpb2 domain 2; RNA polymerase beta subunit; RNA polymerase Rpb2 domain 3; KEGG: mmp:MMP1361 DNA-directed RNA polymerase subunit B; Belongs to the RNA polymerase beta chain family.
  
 
 0.976
Your Current Organism:
Methanococcus aeolicus
NCBI taxonomy Id: 419665
Other names: M. aeolicus Nankai-3, Methanococcus aeolicus Nankai-3, Methanococcus aeolicus str. Nankai-3, Methanococcus aeolicus strain Nankai-3
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