STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Maeo_1410tRNA (cytidine(56)-2'-O)-methyltransferase; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family (180 aa)    
Predicted Functional Partners:
Maeo_1151
TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: mja:MJ0778 hypothetical protein
     0.927
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
 
     0.812
Maeo_1032
PFAM: helix-turn-helix domain protein; KEGG: mmp:MMP1646 conserved hypothetical archaeal protein
 
     0.744
tgtA
tRNA-guanine(15) transglycosylase; Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family
 
     0.723
dcd
Probable dCTP deaminase; TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: mmp:MMP1426 bifunctional dCTP deaminase/dUTP diphosphatase; Belongs to the dCTP deaminase family
       0.709
Maeo_0275
PFAM: protein of unknown function Met10; KEGG: mmp:MMP0323 hypothetical protein
 
   
 0.708
nac
Nascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome
 
     0.647
cobS
Adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate; Belongs to the CobS family
       0.645
Maeo_1489
PFAM: phosphatidylglycerophosphatase A; KEGG: mmp:MMP1597 hypothetical protein
       0.632
Maeo_0313
SMART: Nucleotide binding protein PINc; KEGG: mmp:MMP0374 hypothetical protein
 
     0.613
Your Current Organism:
Methanococcus aeolicus
NCBI taxonomy Id: 419665
Other names: M. aeolicus Nankai-3, Methanococcus aeolicus, Methanococcus aeolicus Nankai-3, Methanococcus aeolicus str. Nankai-3, Methanococcus aeolicus strain Nankai-3
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