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dnaJ protein (Geobacillus thermodenitrificans) - STRING interaction network
"dnaJ" - Heat-shock protein DnaJ in Geobacillus thermodenitrificans
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaJHeat-shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (381 aa)    
Predicted Functional Partners:
dnaK
Heat-shock protein DnaK; Acts as a chaperone (605 aa)
 
  0.999
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (220 aa)
 
 
  0.998
prmA
Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11 (312 aa)
   
   
  0.977
GTNG_0078
Negative regulator of genetic competence ClpC/MecB (811 aa)
   
 
  0.976
GTNG_0856
ATP-dependent Clp protease-like protein (711 aa)
   
 
  0.975
clpB
ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE (861 aa)
   
 
  0.974
groL
GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (540 aa)
 
 
  0.941
hrcA
Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (333 aa)
   
   
  0.878
pheS
phenylalanyl-tRNA synthetase subunit alpha (344 aa)
 
      0.867
GTNG_2437
16S ribosomal RNA methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (258 aa)
   
        0.860
Your Current Organism:
Geobacillus thermodenitrificans
NCBI taxonomy Id: 420246
Other names: Bacillus denitrificans, Bacillus thermodenitrificans, G. thermodenitrificans, G. thermodenitrificans NG80-2, Geobacillus sp. A333, Geobacillus sp. F84a, Geobacillus thermodenitrificans, Geobacillus thermodenitrificans (Manachini et al. 2000) Nazina et al. 2001, Geobacillus thermodenitrificans NG80-2, Geobacillus thermodenitrificans str. NG80-2, Geobacillus thermodenitrificans strain NG80-2
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