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hisA protein (Geobacillus thermodenitrificans) - STRING interaction network
"hisA" - 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase in Geobacillus thermodenitrificans
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (245 aa)    
Predicted Functional Partners:
hisI
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (215 aa)
 
  0.999
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (213 aa)
 
  0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (252 aa)
 
 
0.999
hisB
Imidazoleglycerol-phosphate dehydratase (195 aa)
 
   
  0.993
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (441 aa)
 
   
  0.993
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (207 aa)
 
 
  0.989
hisC
Histidinol-phosphate aminotransferase (365 aa)
   
   
  0.912
trpC
Indole-3-glycerol phosphate synthase (258 aa)
   
 
  0.871
GTNG_2195
Aminotransferase (356 aa)
   
   
  0.858
GTNG_2138
Anthranilate synthase component I (508 aa)
       
  0.790
Your Current Organism:
Geobacillus thermodenitrificans
NCBI taxonomy Id: 420246
Other names: Bacillus denitrificans, Bacillus thermodenitrificans, G. thermodenitrificans, G. thermodenitrificans NG80-2, Geobacillus sp. A333, Geobacillus sp. F84a, Geobacillus thermodenitrificans, Geobacillus thermodenitrificans (Manachini et al. 2000) Nazina et al. 2001, Geobacillus thermodenitrificans NG80-2, Geobacillus thermodenitrificans str. NG80-2, Geobacillus thermodenitrificans strain NG80-2
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