STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCHistidinol-phosphate aminotransferase, HisC; COG0079. (366 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydrogenase, HisB; COG0131.
 
 0.999
hisD
Histidinol dehydrogenase, HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.991
Msm_1052
Prephenate dehydratase, PheA; COG0077.
 
 
 0.942
Msm_0788
Aspartate aminotransferase; COG0436.
 
 
0.938
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide (ProFAR) isomerase, HisA; COG0106.
  
 0.929
cobQ
Cobyric acid synthase, CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.928
Msm_0641
Prephenate dehydrogenase (NADP+); COG0287.
 
  
 0.927
Msm_0610
Aspartate aminotransferase; COG0436.
  
  
 
0.916
hisI
phosphoribosyl-AMP cyclohydrolase, HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.913
hisF
Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.912
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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