node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msm_0721 | Msm_1383 | Msm_0721 | Msm_1383 | Adenylate cyclase, class 2; COG1437. | Anaerobic ribonucleoside-triphosphate reductase, NrdD; COG1328. | 0.900 |
Msm_0721 | moaA | Msm_0721 | Msm_1406 | Adenylate cyclase, class 2; COG1437. | Molybdopterin cofactor biosynthesis protein A, MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.817 |
Msm_0721 | mptA | Msm_0721 | Msm_1033 | Adenylate cyclase, class 2; COG1437. | Conserved hypothetical protein Msm_1033; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.804 |
Msm_0721 | ndk | Msm_0721 | Msm_0203 | Adenylate cyclase, class 2; COG1437. | Nucleoside diphosphate kinase, Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.914 |
Msm_1032 | Msm_1034 | Msm_1032 | Msm_1034 | Transcriptional regulator, Lrp family; COG1522. | Conserved hypothetical protein Msm_1034; COG4077. | 0.609 |
Msm_1032 | cofG | Msm_1032 | Msm_1035 | Transcriptional regulator, Lrp family; COG1522. | FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis); Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.597 |
Msm_1032 | mptA | Msm_1032 | Msm_1033 | Transcriptional regulator, Lrp family; COG1522. | Conserved hypothetical protein Msm_1033; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.609 |
Msm_1034 | Msm_1032 | Msm_1034 | Msm_1032 | Conserved hypothetical protein Msm_1034; COG4077. | Transcriptional regulator, Lrp family; COG1522. | 0.609 |
Msm_1034 | cofG | Msm_1034 | Msm_1035 | Conserved hypothetical protein Msm_1034; COG4077. | FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis); Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.883 |
Msm_1034 | mptA | Msm_1034 | Msm_1033 | Conserved hypothetical protein Msm_1034; COG4077. | Conserved hypothetical protein Msm_1033; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.884 |
Msm_1383 | Msm_0721 | Msm_1383 | Msm_0721 | Anaerobic ribonucleoside-triphosphate reductase, NrdD; COG1328. | Adenylate cyclase, class 2; COG1437. | 0.900 |
Msm_1383 | moaA | Msm_1383 | Msm_1406 | Anaerobic ribonucleoside-triphosphate reductase, NrdD; COG1328. | Molybdopterin cofactor biosynthesis protein A, MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.835 |
Msm_1383 | mptA | Msm_1383 | Msm_1033 | Anaerobic ribonucleoside-triphosphate reductase, NrdD; COG1328. | Conserved hypothetical protein Msm_1033; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.825 |
Msm_1383 | ndk | Msm_1383 | Msm_0203 | Anaerobic ribonucleoside-triphosphate reductase, NrdD; COG1328. | Nucleoside diphosphate kinase, Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.921 |
cofG | Msm_1032 | Msm_1035 | Msm_1032 | FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis); Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | Transcriptional regulator, Lrp family; COG1522. | 0.597 |
cofG | Msm_1034 | Msm_1035 | Msm_1034 | FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis); Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | Conserved hypothetical protein Msm_1034; COG4077. | 0.883 |
cofG | mptA | Msm_1035 | Msm_1033 | FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis); Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | Conserved hypothetical protein Msm_1033; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.899 |
mfnA | mptA | Msm_0987 | Msm_1033 | Tyrosine decarboxylase, MfnA; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | Conserved hypothetical protein Msm_1033; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.560 |
moaA | Msm_0721 | Msm_1406 | Msm_0721 | Molybdopterin cofactor biosynthesis protein A, MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | Adenylate cyclase, class 2; COG1437. | 0.817 |
moaA | Msm_1383 | Msm_1406 | Msm_1383 | Molybdopterin cofactor biosynthesis protein A, MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | Anaerobic ribonucleoside-triphosphate reductase, NrdD; COG1328. | 0.835 |