STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uppPUndecaprenyl-diphosphatase, UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). (277 aa)    
Predicted Functional Partners:
ilvE
Branched-chain-amino-acid aminotransferase, IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
    0.850
uppS
Undecaprenyl pyrophosphate synthase, UppS; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
 
  
 0.718
Msm_1582
Conserved hypothetical membrane protein Msm_1582; COG2035.
 
  
 0.639
Msm_1203
Zn-dependent protease, peptidase M48 family; COG0501.
     
 0.627
nadK
Poly(P)/ATP NAD kinase, inositol monophosphatase family, PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
   
 0.623
Msm_0160
Asparagine synthetase, AsnB; COG0367.
  
  
 0.591
rsmA
Dimethyladenosine transferase, KsgA; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
  
  
 0.589
rnz
Ribonuclease Z (zinc-dependent), beta-lactamase superfamily, ElaC; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
  
  
 0.536
Msm_0493
Mechanosensitive ion channel protein, Sm-like ribonucleoprotein superfamily, MscS; COG0668.
 
  
 0.533
Msm_0227
hydroxymethylglutaryl-CoA (HMG-CoA) reductase, HmgA; COG1257; Belongs to the HMG-CoA reductase family.
      
 0.493
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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