node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msm_0896 | Msm_1117 | Msm_0896 | Msm_1117 | precorrin-6X reductase, CbiJ; COG2099. | Cobalamin biosynthesis protein N, CobN; COG1429. | 0.547 |
Msm_0896 | Msm_1234 | Msm_0896 | Msm_1234 | precorrin-6X reductase, CbiJ; COG2099. | cobalt-precorrin-8X methylmutase, CbiC; COG2082. | 0.973 |
Msm_0896 | Msm_1351 | Msm_0896 | Msm_1351 | precorrin-6X reductase, CbiJ; COG2099. | Precorrin-2 C20-methyltransferase, CbiL; COG2243; Belongs to the precorrin methyltransferase family. | 0.999 |
Msm_0896 | cbiA | Msm_0896 | Msm_1215 | precorrin-6X reductase, CbiJ; COG2099. | Cobyrinic acid a,c-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.999 |
Msm_0896 | cbiT | Msm_0896 | Msm_0238 | precorrin-6X reductase, CbiJ; COG2099. | precorrin-6B methylase, CbiT; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.999 |
Msm_0896 | cbiX | Msm_0896 | Msm_1281 | precorrin-6X reductase, CbiJ; COG2099. | Sirohydrochlorin cobaltochelatase-related protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.999 |
Msm_0896 | cobQ | Msm_0896 | Msm_1565 | precorrin-6X reductase, CbiJ; COG2099. | Cobyric acid synthase, CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.780 |
Msm_0896 | cobS | Msm_0896 | Msm_0933 | precorrin-6X reductase, CbiJ; COG2099. | Cobalamin-5-phosphate synthase, CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.999 |
Msm_0896 | hemA | Msm_0896 | Msm_0967 | precorrin-6X reductase, CbiJ; COG2099. | glutamyl-tRNA reductase, HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.999 |
Msm_1117 | Msm_0896 | Msm_1117 | Msm_0896 | Cobalamin biosynthesis protein N, CobN; COG1429. | precorrin-6X reductase, CbiJ; COG2099. | 0.547 |
Msm_1117 | Msm_1234 | Msm_1117 | Msm_1234 | Cobalamin biosynthesis protein N, CobN; COG1429. | cobalt-precorrin-8X methylmutase, CbiC; COG2082. | 0.557 |
Msm_1117 | Msm_1351 | Msm_1117 | Msm_1351 | Cobalamin biosynthesis protein N, CobN; COG1429. | Precorrin-2 C20-methyltransferase, CbiL; COG2243; Belongs to the precorrin methyltransferase family. | 0.728 |
Msm_1117 | Msm_1715 | Msm_1117 | Msm_1715 | Cobalamin biosynthesis protein N, CobN; COG1429. | Magnesium chelatase subunit; COG1429. | 0.930 |
Msm_1117 | cbiA | Msm_1117 | Msm_1215 | Cobalamin biosynthesis protein N, CobN; COG1429. | Cobyrinic acid a,c-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.974 |
Msm_1117 | cbiT | Msm_1117 | Msm_0238 | Cobalamin biosynthesis protein N, CobN; COG1429. | precorrin-6B methylase, CbiT; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.590 |
Msm_1117 | cbiX | Msm_1117 | Msm_1281 | Cobalamin biosynthesis protein N, CobN; COG1429. | Sirohydrochlorin cobaltochelatase-related protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.406 |
Msm_1117 | cobQ | Msm_1117 | Msm_1565 | Cobalamin biosynthesis protein N, CobN; COG1429. | Cobyric acid synthase, CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.531 |
Msm_1117 | cobS | Msm_1117 | Msm_0933 | Cobalamin biosynthesis protein N, CobN; COG1429. | Cobalamin-5-phosphate synthase, CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.650 |
Msm_1117 | hemA | Msm_1117 | Msm_0967 | Cobalamin biosynthesis protein N, CobN; COG1429. | glutamyl-tRNA reductase, HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.549 |
Msm_1234 | Msm_0896 | Msm_1234 | Msm_0896 | cobalt-precorrin-8X methylmutase, CbiC; COG2082. | precorrin-6X reductase, CbiJ; COG2099. | 0.973 |