STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLGlutamate-1-semialdehyde 2,1-aminomutase, HemL; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (423 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase, HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.992
Msm_1476
Porphobilinogen synthase, HemB; COG0113; Belongs to the ALAD family.
 
 
 0.992
Msm_0881
Porphobilinogen deaminase; COG0181.
 
  
 0.915
Msm_1234
cobalt-precorrin-8X methylmutase, CbiC; COG2082.
     
 0.903
thiE
Thiamine monophosphate synthase, ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
    
 0.759
aspS
aspartyl-tRNA synthetase, AspS; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
  
    0.746
Msm_1504
Uroporphyrinogen III synthase, HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.720
argS
arginyl-tRNA synthetase, ArgS; COG0018; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
   
 0.660
Msm_1232
Signal peptidase I; COG0681.
       0.653
Msm_0446
Citrate synthase, GltA; COG0372.
 
  
 0.652
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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