STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mchN5,N10-methenyl-tetrahydromethanopterin cyclohydrolase, Mch; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa)    
Predicted Functional Partners:
ftr
Formylmethanofuran:tetrahydromethanopterin formyltransferase, Ftr; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
 
 
 0.997
mtd
Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase, Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
 
  
 0.995
Msm_0308
Formylmethanofuran:tetrahydromethanopterin formyltransferase, FtrC; COG2037.
 
 
 0.991
hmd
H(2)-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase (coenzyme F420-dependent), Mth; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
 0.920
Msm_1413
Tungsten formylmethanofuran dehydrogenase, subunit A, FwdA; COG1229.
 
   
 0.913
Msm_1477
ATP:dephospho-CoA triphosphoribosyl transferase; COG1767.
 
     0.833
Msm_1414
Tungsten formylmethanofuran dehydrogenase, subunit C, FwdC; COG2218.
 
   
 0.828
Msm_0848
Predicted sugar kinase, GHMP kinase family; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
 
   
 0.815
Msm_0431
Predicted ATP-dependent carboligase, biotin carboxylase-related; COG2232.
 
     0.808
Msm_1412
Tungsten formylmethanofuran dehydrogenase, subunit B, FwdB; COG1029.
 
   
 0.795
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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