STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A251VM74Putative mitogen-activated protein (MAP) kinase, ERK3/4; Belongs to the protein kinase superfamily. (354 aa)    
Predicted Functional Partners:
ORC3
Putative origin recognition complex subunit 3.
    
   0.642
ORC2
Putative origin of replication complex subunit 2.
    
   0.642
ORC5
Putative origin recognition complex protein 5.
    
   0.642
MCM31
DNA helicase.
    
   0.642
ORC4
Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.
    
   0.540
MCM4
DNA helicase; Belongs to the MCM family.
    
   0.540
MCM8
Putative DNA helicase MCM8; Belongs to the MCM family.
    
   0.540
PDE149
Putative integral membrane TerC family protein.
    
   0.540
MCM6
DNA helicase; Belongs to the MCM family.
    
   0.540
ORC1B
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
    
   0.540
Your Current Organism:
Helianthus annuus
NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.