node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ssed_0959 | Ssed_3739 | Ssed_0959 | Ssed_3739 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.936 |
Ssed_0959 | Ssed_4223 | Ssed_0959 | Ssed_4223 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: ilo:IL1531 short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.936 |
Ssed_0959 | fhs | Ssed_0959 | Ssed_0612 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.940 |
Ssed_0959 | folD | Ssed_0959 | Ssed_1539 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.410 |
Ssed_0959 | gcvT | Ssed_0959 | Ssed_3675 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
Ssed_0959 | glyA | Ssed_0959 | Ssed_1271 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
Ssed_0959 | purH | Ssed_0959 | Ssed_0444 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | IMP cyclohydrolase; KEGG: slo:Shew_3412 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.930 |
Ssed_0959 | purN | Ssed_0959 | Ssed_1844 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.927 |
Ssed_0959 | purT | Ssed_0959 | Ssed_0973 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazole carboxylase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
Ssed_3739 | Ssed_0959 | Ssed_3739 | Ssed_0959 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.936 |
Ssed_3739 | Ssed_4223 | Ssed_3739 | Ssed_4223 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: ilo:IL1531 short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.905 |
Ssed_3739 | fhs | Ssed_3739 | Ssed_0612 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.949 |
Ssed_3739 | folD | Ssed_3739 | Ssed_1539 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.558 |
Ssed_3739 | gcvT | Ssed_3739 | Ssed_3675 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
Ssed_3739 | glyA | Ssed_3739 | Ssed_1271 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
Ssed_3739 | purH | Ssed_3739 | Ssed_0444 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | IMP cyclohydrolase; KEGG: slo:Shew_3412 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.917 |
Ssed_3739 | purN | Ssed_3739 | Ssed_1844 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
Ssed_3739 | purT | Ssed_3739 | Ssed_0973 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylaminoimidazole carboxylase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
Ssed_4223 | Ssed_0959 | Ssed_4223 | Ssed_0959 | KEGG: ilo:IL1531 short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.936 |
Ssed_4223 | Ssed_3739 | Ssed_4223 | Ssed_3739 | KEGG: ilo:IL1531 short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.905 |