STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_0838PFAM: response regulator receiver; metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: mex:Mext_0206 metal-dependent phosphohydrolase HD sub domain. (378 aa)    
Predicted Functional Partners:
M446_4332
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: mex:Mext_3983 diguanylate cyclase.
  
 0.890
M446_2827
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: mex:Mext_3062 diguanylate cyclase.
  
 0.819
M446_1526
Multi-sensor hybrid histidine kinase; KEGG: sat:SYN_01077 sensor proteinLuxQ; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein; GAF domain protein.
 
 0.807
M446_1996
PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mex:Mext_2117 histidine kinase.
 
 0.804
M446_2966
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: mex:Mext_1748 diguanylate cyclase.
  
 0.787
M446_2203
KEGG: rfr:Rfer_1093 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 
 0.782
M446_3321
PAS/PAC sensor hybrid histidine kinase; KEGG: dar:Daro_1934 PAS; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 0.781
M446_1787
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: aeh:Mlg_1012 diguanylate cyclase.
  
 0.768
M446_5358
Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein; KEGG: mex:Mext_3510 ATP-binding region ATPase domain protein.
 
 0.741
M446_5043
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver; KEGG: mex:Mext_1978 diguanylate cyclase.
  
 0.739
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.