STRINGSTRING
M446_4524 protein (Methylobacterium sp. 446) - STRING interaction network
"M446_4524" - N-acetyl-gamma-glutamyl-phosphate reductase in Methylobacterium sp. 446
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_4524N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily (325 aa)    
Predicted Functional Partners:
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily (304 aa)
  0.999
argD
TIGRFAM- acetylornithine and succinylornithine aminotransferase; PFAM- aminotransferase class-III; KEGG- mex-Mext_4075 acetylornithine and succinylornithine aminotransferase (397 aa)
 
 
  0.989
argH
TIGRFAM- argininosuccinate lyase; PFAM- fumarate lyase; KEGG- mex-Mext_3289 argininosuccinate lyase (462 aa)
 
   
  0.916
argG
PFAM- argininosuccinate synthase; KEGG- mex-Mext_2293 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily (413 aa)
 
   
  0.833
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (431 aa)
 
   
  0.822
argJ
Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis- the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate; Belongs to the ArgJ family (412 aa)
 
   
  0.804
M446_6124
PFAM- argininosuccinate synthase; KEGG- ang-An12g01280 hypothetical protein Pfam- Asn_synthase Arginosuc_synth (417 aa)
 
   
  0.804
M446_5028
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde; Belongs to the NAGSA dehydrogenase family. Type 2 subfamily (315 aa)
         
 
0.800
hisB
PFAM- imidazoleglycerol-phosphate dehydratase; KEGG- mex-Mext_2548 imidazoleglycerol-phosphate dehydratase (200 aa)
 
   
  0.760
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (135 aa)
 
   
  0.753
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46, Methylobacterium sp. 446
Server load: low (11%) [HD]