node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
M446_2102 | M446_2260 | M446_2102 | M446_2260 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.835 |
M446_2102 | clpB | M446_2102 | M446_5085 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.844 |
M446_2102 | dnaK | M446_2102 | M446_6270 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
M446_2102 | groL | M446_2102 | M446_1771 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.790 |
M446_2102 | groL-2 | M446_2102 | M446_5463 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.790 |
M446_2102 | grpE | M446_2102 | M446_2184 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | Ribulose-phosphate 3-epimerase; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.956 |
M446_2102 | htpG | M446_2102 | M446_0044 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.969 |
M446_2256 | M446_2260 | M446_2256 | M446_2260 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.768 |
M446_2256 | clpB | M446_2256 | M446_5085 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.768 |
M446_2256 | dnaK | M446_2256 | M446_6270 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.949 |
M446_2256 | groL | M446_2256 | M446_1771 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.701 |
M446_2256 | groL-2 | M446_2256 | M446_5463 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.701 |
M446_2256 | grpE | M446_2256 | M446_2184 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | Ribulose-phosphate 3-epimerase; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.904 |
M446_2256 | htpG | M446_2256 | M446_0044 | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.969 |
M446_2260 | M446_2102 | M446_2260 | M446_2102 | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: mex:Mext_4293 heat shock protein DnaJ domain protein. | 0.835 |
M446_2260 | M446_2256 | M446_2260 | M446_2256 | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; KEGG: rpd:RPD_3059 heat shock protein DnaJ-like. | 0.768 |
M446_2260 | M446_6495 | M446_2260 | M446_6495 | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; KEGG: mex:Mext_3231 heat shock protein DnaJ domain protein. | 0.768 |
M446_2260 | dnaJ | M446_2260 | M446_6271 | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.843 |
M446_2260 | dnaK | M446_2260 | M446_6270 | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.965 |
M446_2260 | groL | M446_2260 | M446_1771 | KEGG: mex:Mext_4802 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.622 |