node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACB24118.1 | ACB25643.1 | Mrad2831_2123 | Mrad2831_3667 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | 0.536 |
ACB24118.1 | ACB26492.1 | Mrad2831_2123 | Mrad2831_4526 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.924 |
ACB24118.1 | fhs | Mrad2831_2123 | Mrad2831_4072 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.955 |
ACB24118.1 | glyA | Mrad2831_2123 | Mrad2831_3956 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
ACB24118.1 | purH | Mrad2831_2123 | Mrad2831_5593 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.919 |
ACB24118.1 | purN | Mrad2831_2123 | Mrad2831_0490 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.922 |
ACB25643.1 | ACB24118.1 | Mrad2831_3667 | Mrad2831_2123 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.536 |
ACB25643.1 | fhs | Mrad2831_3667 | Mrad2831_4072 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.954 |
ACB25643.1 | purH | Mrad2831_3667 | Mrad2831_5593 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.922 |
ACB25643.1 | purN | Mrad2831_3667 | Mrad2831_0490 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.919 |
ACB26492.1 | ACB24118.1 | Mrad2831_4526 | Mrad2831_2123 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.924 |
ACB26492.1 | fhs | Mrad2831_4526 | Mrad2831_4072 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.928 |
ACB26492.1 | glyA | Mrad2831_4526 | Mrad2831_3956 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
ACB26492.1 | purH | Mrad2831_4526 | Mrad2831_5593 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.925 |
ACB26492.1 | purN | Mrad2831_4526 | Mrad2831_0490 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.921 |
fhs | ACB24118.1 | Mrad2831_4072 | Mrad2831_2123 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.955 |
fhs | ACB25643.1 | Mrad2831_4072 | Mrad2831_3667 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | 0.954 |
fhs | ACB26492.1 | Mrad2831_4072 | Mrad2831_4526 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.928 |
fhs | glyA | Mrad2831_4072 | Mrad2831_3956 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
fhs | purC | Mrad2831_4072 | Mrad2831_2949 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: SAICAR synthetase; KEGG: rle:RL3872 putative phosphoribosylamidoimidazole-succinocarboxamide synthase. | 0.875 |