node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACB24065.1 | ACB24291.1 | Mrad2831_2070 | Mrad2831_2296 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.962 |
ACB24065.1 | ACB26264.1 | Mrad2831_2070 | Mrad2831_4297 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: conserved hypothetical protein; KEGG: mex:Mext_1495 hypothetical protein. | 0.448 |
ACB24065.1 | ACB26637.1 | Mrad2831_2070 | Mrad2831_4671 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.520 |
ACB24065.1 | ACB27576.1 | Mrad2831_2070 | Mrad2831_5631 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mex:Mext_4238 porphobilinogen synthase; Belongs to the ALAD family. | 0.895 |
ACB24065.1 | hemC | Mrad2831_2070 | Mrad2831_2839 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.989 |
ACB24065.1 | hemE | Mrad2831_2070 | Mrad2831_4298 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.943 |
ACB24065.1 | hemH | Mrad2831_2070 | Mrad2831_0734 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.481 |
ACB24291.1 | ACB24065.1 | Mrad2831_2296 | Mrad2831_2070 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.962 |
ACB24291.1 | ACB25077.1 | Mrad2831_2296 | Mrad2831_3095 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: ccr:CC_1101 hypothetical protein. | 0.505 |
ACB24291.1 | ACB26523.1 | Mrad2831_2296 | Mrad2831_4557 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hypothetical protein; KEGG: gdi:GDI1716 putative amine oxidase. | 0.505 |
ACB24291.1 | ACB26637.1 | Mrad2831_2296 | Mrad2831_4671 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.447 |
ACB24291.1 | ACB27576.1 | Mrad2831_2296 | Mrad2831_5631 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mex:Mext_4238 porphobilinogen synthase; Belongs to the ALAD family. | 0.926 |
ACB24291.1 | hemC | Mrad2831_2296 | Mrad2831_2839 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
ACB24291.1 | hemE | Mrad2831_2296 | Mrad2831_4298 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.954 |
ACB24291.1 | hemH | Mrad2831_2296 | Mrad2831_0734 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.554 |
ACB25077.1 | ACB24291.1 | Mrad2831_3095 | Mrad2831_2296 | PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: ccr:CC_1101 hypothetical protein. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.505 |
ACB25077.1 | ACB26523.1 | Mrad2831_3095 | Mrad2831_4557 | PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: ccr:CC_1101 hypothetical protein. | Hypothetical protein; KEGG: gdi:GDI1716 putative amine oxidase. | 0.650 |
ACB25077.1 | ACB27576.1 | Mrad2831_3095 | Mrad2831_5631 | PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: ccr:CC_1101 hypothetical protein. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mex:Mext_4238 porphobilinogen synthase; Belongs to the ALAD family. | 0.400 |
ACB25077.1 | hemE | Mrad2831_3095 | Mrad2831_4298 | PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: ccr:CC_1101 hypothetical protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.859 |
ACB25077.1 | hemH | Mrad2831_3095 | Mrad2831_0734 | PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: ccr:CC_1101 hypothetical protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.832 |