node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR65843.1 | hisA | MmarC7_0776 | MmarC7_1415 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | 0.682 |
ABR65843.1 | hisB | MmarC7_0776 | MmarC7_1567 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | 0.536 |
ABR65843.1 | hisC | MmarC7_0776 | MmarC7_0463 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. | 0.971 |
ABR65843.1 | hisE | MmarC7_0776 | MmarC7_1048 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmp:MMP0051 phosphoribosyl-ATP pyrophosphatase. | 0.494 |
ABR65843.1 | hisF | MmarC7_0776 | MmarC7_0997 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.499 |
ABR65843.1 | hisG | MmarC7_0776 | MmarC7_0194 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.594 |
ABR65843.1 | hisH | MmarC7_0776 | MmarC7_1259 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.560 |
ABR65843.1 | hisI | MmarC7_0776 | MmarC7_1283 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.454 |
cobQ | hisC | MmarC7_0462 | MmarC7_0463 | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. | 0.975 |
hisA | ABR65843.1 | MmarC7_1415 | MmarC7_0776 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | 0.682 |
hisA | hisB | MmarC7_1415 | MmarC7_1567 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | 0.992 |
hisA | hisC | MmarC7_1415 | MmarC7_0463 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. | 0.991 |
hisA | hisD | MmarC7_1415 | MmarC7_0213 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisE | MmarC7_1415 | MmarC7_1048 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmp:MMP0051 phosphoribosyl-ATP pyrophosphatase. | 0.985 |
hisA | hisF | MmarC7_1415 | MmarC7_0997 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | MmarC7_1415 | MmarC7_0194 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.995 |
hisA | hisH | MmarC7_1415 | MmarC7_1259 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | MmarC7_1415 | MmarC7_1283 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | ABR65843.1 | MmarC7_1567 | MmarC7_0776 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. | 0.536 |
hisB | hisA | MmarC7_1567 | MmarC7_1415 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | 0.992 |