node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR65386.1 | ABR65426.1 | MmarC7_0316 | MmarC7_0357 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain. | 0.864 |
ABR65386.1 | ABR66207.1 | MmarC7_0316 | MmarC7_1141 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | 0.898 |
ABR65386.1 | ABR66616.1 | MmarC7_0316 | MmarC7_1558 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. | 0.873 |
ABR65386.1 | ABR66732.1 | MmarC7_0316 | MmarC7_1674 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0650 acetohydroxyacid synthase large subunit. | 0.957 |
ABR65386.1 | ABR66733.1 | MmarC7_0316 | MmarC7_1675 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0651 acetohydroxyacid synthase small subunit. | 0.935 |
ABR65386.1 | ilvC | MmarC7_0316 | MmarC7_1680 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.787 |
ABR65386.1 | leuC | MmarC7_0316 | MmarC7_0399 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.971 |
ABR65386.1 | leuC-2 | MmarC7_0316 | MmarC7_0724 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.847 |
ABR65386.1 | leuD | MmarC7_0316 | MmarC7_1135 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.969 |
ABR65386.1 | leuD-2 | MmarC7_0316 | MmarC7_1379 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.850 |
ABR65426.1 | ABR65386.1 | MmarC7_0357 | MmarC7_0316 | TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain. | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.864 |
ABR65426.1 | ABR66616.1 | MmarC7_0357 | MmarC7_1558 | TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. | 0.827 |
ABR66207.1 | ABR65386.1 | MmarC7_1141 | MmarC7_0316 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.898 |
ABR66207.1 | ABR66616.1 | MmarC7_1141 | MmarC7_1558 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. | 0.950 |
ABR66207.1 | ABR66732.1 | MmarC7_1141 | MmarC7_1674 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0650 acetohydroxyacid synthase large subunit. | 0.917 |
ABR66207.1 | ABR66733.1 | MmarC7_1141 | MmarC7_1675 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0651 acetohydroxyacid synthase small subunit. | 0.998 |
ABR66207.1 | ilvC | MmarC7_1141 | MmarC7_1680 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.986 |
ABR66207.1 | leuC | MmarC7_1141 | MmarC7_0399 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.553 |
ABR66207.1 | leuC-2 | MmarC7_1141 | MmarC7_0724 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.494 |
ABR66207.1 | leuD | MmarC7_1141 | MmarC7_1135 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.614 |