STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (355 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 0.999
EDS74218.1
Chorismate mutase; KEGG: aae:aq_951 3.3e-53 pheA; chorismate mutase/prephenate dehydratase K04093:K04518; COG: COG0077 Prephenate dehydratase; Psort location: Cytoplasmic, score: 9.98.
 
 
 0.997
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
  
 0.994
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.983
nifJ
KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.955
EDS75227.1
KEGG: cno:NT01CX_0626 1.1e-70 prephenate dehydrogenase K00210; COG: COG0287 Prephenate dehydrogenase; Psort location: Cytoplasmic, score: 8.87.
 
 0.923
EDS76069.1
Glutamine amidotransferase, class I; KEGG: tte:TTE1582 3.1e-57 pabA; anthranilate/para-aminobenzoate synthases component II K01658; COG: COG0512 Anthranilate/para-aminobenzoate synthases component II; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.918
EDS75892.1
Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 
 0.906
aroF-2
3-deoxy-7-phosphoheptulonate synthase; KEGG: cac:CAC0892 6.4e-114 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; COG: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.898
EDS76068.1
Chorismate binding enzyme; KEGG: aae:aq_582 1.8e-100 trpE; anthranilate synthase component I K01657; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.876
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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