STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IGFBP1Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). (272 aa)    
Predicted Functional Partners:
IGF1
Insulin like growth factor 1.
   
 0.993
IGFBP4
Insulin like growth factor binding protein 4.
    
 
0.944
IGF2
Insulin like growth factor 2.
   
 0.927
AHSG
Alpha 2-HS glycoprotein.
   
  
 0.793
SPP2
Secreted phosphoprotein 2.
   
    0.780
CORIN
Corin, serine peptidase.
    
 0.589
FAM20C
FAM20C golgi associated secretory pathway kinase.
    
 0.566
IGF1R
Tyrosine-protein kinase receptor.
    
 
 0.563
IGFBP6
Insulin like growth factor binding protein 6.
      
0.556
IGFALS
Insulin like growth factor binding protein acid labile subunit.
    
 0.525
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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